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. 1989;7(12):1473-7.
doi: 10.1016/0731-7085(89)80153-0.

Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B

M Subhashini  1 , M S Subramanian, V R Rao
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Determination of isoniazid in pharmaceutical preparations by reaction with radiochloramine-B

M Subhashini et al. J Pharm Biomed Anal. 1989.

Abstract

A method has been developed for the determination of isoniazid (INH) at microgram level in pharmaceutical preparations based on the oxidation of isoniazid by radiochloramine-B. Interference of vitamin C has been overcome by precipitation as lead ascorbate and that of rifampicin and p-aminosalicylic acid by selective extraction. Amounts as low as 25 micrograms of INH can be determined.

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