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. 1989;7(12):1811-7.
doi: 10.1016/0731-7085(89)80198-0.

Determination of opiates and other basic drugs by high-performance liquid chromatography with electrochemical detection

J G Besner  1 , C Band, J J Rondeau, L Yamlahi, G Caillé, F Varin, J Stewart
Affiliations

Determination of opiates and other basic drugs by high-performance liquid chromatography with electrochemical detection

J G Besner et al. J Pharm Biomed Anal. 1989.

Abstract

A procedure is described for the extraction and determination of morphine (M), hydromorphone (HM), codeine (C) and metoclopramide (MCP) present in human plasma. The drugs are separated by reversed-phase liquid chromatography and detected amperometrically at a glassy carbon electrode. The method provides high sensitivity and selectivity and has been used successfully in bioavailability studies.

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