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Editorial
. 2014;13(13):2017-8.
doi: 10.4161/cc.29460. Epub 2014 Jun 6.

Targeting the Achilles' heel of drug-resistant cancer stem cells

Laetitia Seguin  1 , Maricel Gozo  1 , Sara M Weis  1 , David A Cheresh  1
Affiliations
Editorial

Targeting the Achilles' heel of drug-resistant cancer stem cells

Laetitia Seguin et al. Cell Cycle. 2014.
No abstract available

Keywords: EGFR-TKI resistance; KRAS; NFkB; cancer stem cells; integrin β3.

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Figures

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Figure 1. Integrin β3 drives EGFR TKI resistance. Integrin β3 interacts with KRAS to promote RalB activation, resulting in the activation of the NFκB pathway and thereby promoting cell survival. Importantly, ligation of integrin is not required for this signaling cascade. The inhibition of this non-canonical pathway sensitizes β3-positive tumor cells to EGFR TKI. Pharmacologic inhibition of this pathway can reverse cancer stemness and drug resistance.
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References

    1. Visvader JE, et al. Nat Rev Cancer. 2008;8:755–68. doi: 10.1038/nrc2499. - DOI - PubMed
    1. Medema JP. Nat Cell Biol. 2013;15:338–44. doi: 10.1038/ncb2717. - DOI - PubMed
    1. Desgrosellier JS, et al. Nat Med. 2009;15:1163–9. doi: 10.1038/nm.2009. - DOI - PMC - PubMed
    1. Seguin L, et al. Nat Cell Biol. 2014;16:457–68. doi: 10.1038/ncb2953. - DOI - PMC - PubMed
    1. Kashpur O, et al. BMC Genomics. 2013;14:656. doi: 10.1186/1471-2164-14-656. - DOI - PMC - PubMed

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