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Review
. 2015;36(3):221-32.
doi: 10.1080/15321819.2014.924418.

Association of plasma interleukin-18 levels and polymorphisms in interleukin-18 gene with outcomes of hepatitis C virus infections: a meta-analysis

Zhi Li Niu  1 , Ping An Zhang, Yong Qing Tong
Affiliations
Review

Association of plasma interleukin-18 levels and polymorphisms in interleukin-18 gene with outcomes of hepatitis C virus infections: a meta-analysis

Zhi Li Niu et al. J Immunoassay Immunochem. 2015.

Abstract

Several polymorphisms in the interleukin-18 (IL-18) gene and plasma IL-18 levels have been reported to influence hepatitis C virus (HCV) infection. However, the published findings have been conflicting. We conducted meta-analyses of randomized, controlled trials to address the association of IL-18 polymorphisms and plasma IL-18 levels and the outcomes of HCV infection. The results showed that there was no evidence for an association between the HCV infections and the polymorphisms genotypes of IL-18. However, plasma IL-18 levels were found higher in HCV infection patients than in healthy controls. The pooled SMD was 2.911(95% CI 2.556-3.265, z = 16.09, P < 0.001).

Keywords: Chronic hepatitis C; IL-18; Meta-analysis; Plasma; Polymorphisms.

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