Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014;13(13):2019-20.
doi: 10.4161/cc.29461. Epub 2014 Jun 6.

Izumo meets Juno: preventing polyspermy in fertilization

Enrica Bianchi  1 , Gavin J Wright  1
Affiliations
Editorial

Izumo meets Juno: preventing polyspermy in fertilization

Enrica Bianchi et al. Cell Cycle. 2014.
No abstract available

Keywords: Izumo1; Juno; fertilization; polyspermy block.

PubMed Disclaimer

Figures

None
Figure 1. Juno–Izumo binding is essential for fertilization and may contribute to the membrane block to polyspermy. Izumo (red) is displayed on the surface of acrosome-reacted sperm and interacts with Juno (green) on the surface of ovulated eggs. Following fertilization, Juno is rapidly shed from the egg membrane and redistributed as vesicles, which may bind and rapidly neutralize subsequent incoming acrosome-reacted sperm, thereby reducing the possibility of creating nonviable polyploid embryos.
See this image and copyright information in PMC

Comment on

References

    1. Inoue N, et al. Nature. 2005;434:234–8. doi: 10.1038/nature03362. - DOI - PubMed
    1. Wright GJ. Mol Biosyst. 2009;5:1405–12. doi: 10.1039/b903580j. - DOI - PMC - PubMed
    1. Bianchi E, et al. Nature. 2014;508:483–7. doi: 10.1038/nature13203. - DOI - PMC - PubMed
    1. Jaffe LA. Nature. 1976;261:68–71. doi: 10.1038/261068a0. - DOI - PubMed
    1. Austin CR, et al. Aust J Biol Sci. 1953;6:674–92. - PubMed

LinkOut - more resources