Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:1170:29-40.
doi: 10.1007/978-1-4939-0888-2_2.

Cell cycle regulation by checkpoints

Kevin J Barnum  1 , Matthew J O'Connell
Affiliations

Cell cycle regulation by checkpoints

Kevin J Barnum et al. Methods Mol Biol. 2014.

Abstract

Cell cycle checkpoints are surveillance mechanisms that monitor the order, integrity, and fidelity of the major events of the cell cycle. These include growth to the appropriate cell size, the replication and integrity of the chromosomes, and their accurate segregation at mitosis. Many of these mechanisms are ancient in origin and highly conserved, and hence have been heavily informed by studies in simple organisms such as the yeasts. Others have evolved in higher organisms, and control alternative cell fates with significant impact on tumor suppression. Here, we consider these different checkpoint pathways and the consequences of their dysfunction on cell fate.

PubMed Disclaimer

References

    1. Mitchison JM. The fission yeast, Schizosaccharomyces pombe. Bioessays. 1990;12(4):189–191. - PubMed
    1. Mitchison JM, Nurse P. Growth in cell length in the fission yeast Schizosaccharomyces pombe. J Cell Sci. 1985;75:357–376. - PubMed
    1. Mitchison JM. The growth of single cells. I. Schizosaccharomyces pombe. Exp Cell Res. 1957;13(2):244–262. - PubMed
    1. Fantes PA. Control of cell size and cycle time in Schizosaccharomyces pombe. J Cell Sci. 1977;24(51):51–67. - PubMed
    1. Rao PN, Johnson RT. Mammalian cell fusion. IV. Regulation of chromosome formation from interphase nuclei by various chemical compounds. J Cell Physiol. 1971;78(2):217–223. - PubMed

Publication types