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Comment
. 2014 Jul 17;33(14):1511-3.
doi: 10.15252/embj.201488980. Epub 2014 Jun 6.

'From blood to blood': de-differentiation of hematopoietic progenitors to stem cells

Carlos-Filipe Pereira  1 , Ihor R Lemischka  1 , Kateri Moore  1
Affiliations
Comment

'From blood to blood': de-differentiation of hematopoietic progenitors to stem cells

Carlos-Filipe Pereira et al. EMBO J. .

Abstract

Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.

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Figures

Figure 1
Figure 1. Strategies to induce hematopoietic stem cells
(A) Strategies for the induction of hematopoietic stem cells (HSCs) and hemogenic endothelial cells (HE) from fibroblasts (Szabo et al, ; Pereira et al, 2013), embryonic/induced pluripotent stem cells (ESC/iPSC) (Doulatov et al, 2013), or committed blood progenitors (Riddell et al, 2014). The transcription factors used for each induction are highlighted. (B) Advantages and disadvantages of fibroblasts, ESC/iPSCs, and blood cell types as a cell source for inducing HSCs. The disadvantages of starting with blood cells are highlighted.
See this image and copyright information in PMC

Comment on

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