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Editorial
. 2014 Sep;155(9):1677-1678.
doi: 10.1016/j.pain.2014.05.028. Epub 2014 Jun 4.

An SCN9A variant, known to cause pain, is now found to cause itch

Affiliations
Editorial

An SCN9A variant, known to cause pain, is now found to cause itch

Lindsey M Snyder et al. Pain. 2014 Sep.
No abstract available

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References

    1. Devigili G, Eleopra R, Pierro T, Lombardi R, Rinaldo S, Lettieri C, Faber CG, Merkies ISJ, Waxman SG, Lauria G. Paroxysmal itch caused by gain-of-function Nav1.7 mutation. PAIN® 2014;155:1702–1707.
    1. Dib-Hajj SD, Yang Y, Black JA, Waxman SG. The Na(V)1.7 sodium channel: from molecule to man. Nat Rev Neurosci. 2013;14:49-62.
    1. Faber CG, Lauria G, Merkies IS, Cheng X, Han C, Ahn HS, Persson AK, Hoeijmakers JG, Gerrits MM, Pierro T, Lombardi R, Kapetis D, Dib-Hajj SD, Waxman SG. Gain-of-function Nav1.8 mutations in painful neuropathy. Proc Natl Acad Sci U S A. 2012;109:19444-19449.
    1. Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N, Wood JN, Gardiner RM, Rees M. SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron. 2006;52:767-774.
    1. Han C, Dib-Hajj SD, Lin Z, Li Y, Eastman EM, Tyrrell L, Cao X, Yang Y, Waxman SG. Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain. 2009;132:1711-1722.

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