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. 2015 Feb;29(2):371-376.
doi: 10.1111/jdv.12567. Epub 2014 Jun 9.

Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa

E Shavit  1   2 , J Dreiher  3   4 , T Freud  4 , S Halevy  1   2 , S Vinker  5   6 , A D Cohen  4   5
Affiliations

Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa

E Shavit et al. J Eur Acad Dermatol Venereol. 2015 Feb.

Abstract

Background: Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease affecting skin that bears apocrine glands. Only anecdotal reports and a few small studies have demonstrated a possible association between HS and depression, but these studies were uncontrolled or were based on small sample sizes. To the best of our knowledge, the association between HS and other psychiatric disorders has never been investigated.

Objectives: To investigate the association between HS and psychiatric disorders: depression, anxiety, psychoses, schizophrenia and bipolar disorder.

Methods: A cross-sectional study was conducted utilizing the database of Clalit Health Services (over 4,100,000 patients). Case patients were defined as having HS when diagnosed by a dermatologist. Control patients without HS were age and gender matched in a 2 : 1 manner. The proportions of patients with psychiatric diseases were compared between patients with and without HS. The association between HS and psychiatric diseases was assessed in multivariate models using logistic regression analyses.

Results: The study included 3207 patients with HS and 6412 age- and gender-matched controls. Depression was diagnosed in 5.9% of patients with HS vs. 3.5% of patients without HS (P < 0.001). Anxiety was diagnosed in 3.9% of patients with HS vs. 2.4% of patients without HS (P < 0.001). These associations were significant after controlling for the confounders age and gender (Depression: OR = 1.7, 95% CI: 1.4-2.1; Anxiety: OR = 1.7, 95% CI: 1.3-2.1).

Conclusions: Hidradenitis suppurativa was associated with depression and anxiety. Dermatologists treating patients with HS should be aware of this important association.

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References

    1. Jemec GBE, Revuz J, Leyden JJ (eds). Hidradenitis suppurativa. Springer Verlag, Berlin, 2006.
    1. Hurley HJ. Axillary hyperhidrosis, apocrine bromhidrosis, hidradenitis suppurativa, and familial benign pemphigus: surgical approach. In: Roenigk RK, Roenigk HH Jr, eds. Dermatologic Surgery: Principles and Practice, 2nd edn. Marcel Dekker, New York, 1996: 623-645.
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