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Comparative Study
. 2014 Jun 9;9(6):e99186.
doi: 10.1371/journal.pone.0099186. eCollection 2014.

Insulin-like growth factor-1 as a prognostic marker in patients with acute ischemic stroke

Jian-Hua Tang  1 , Li-Li Ma  1 , Tian-Xia Yu  1 , Juan Zheng  1 , Hui-Juan Zhang  1 , Hui Liang  1 , Peng Shao  1
Affiliations
Comparative Study

Insulin-like growth factor-1 as a prognostic marker in patients with acute ischemic stroke

Jian-Hua Tang et al. PLoS One. .

Retraction in

Abstract

Objective: Insulin-like growth factor-1 (IGF-1) has been associated with cardiovascular risk factors and atherosclerosis. The aim of the present study was to evaluate the prognostic value of IGF-1 levels in patients with acute ischemic stroke (AIS).

Methods: All patients with first-ever AIS from August 1, 2012 to August 31, 2013 were recruited to participate in the study. Clinical data were collected. The National Institutes of Health Stroke Scale (NIHSS) score was assessed on admission blinded to serum IGF-1 levels. For the assessment of functional outcome at 90 days Modified Rankin Scale (mRS) was used. On admission, serum IGF-1 levels were determined by chemiluminescence immunoassay. The influence of IGF-1 levels on functional outcome and death was assessed by multivariate logistic regression analysis.

Results: Patients with an unfavorable outcomes and non-survivors had significantly decreased serum IGF-1 levels on admission (P<0.0001 for both). IGF-1 was an independent prognostic marker of functional outcome and death [odds ratio 0.89 (0.84-0.93) and 0.90 (0.84-0.95), respectively, P<0.0001 for both, adjusted for age, NIHSS score and other predictors] in patients with ischemic stroke. Serum IGF-1 levels ≤130 ng/mL was as an value indicator for unfavorable functional outcome (OR 3.31, 95% CI:1.87-5.62; P<0.0001), after adjusting for other significant confounders.

Conclusions: We reported a significant association between low serum IGF-1 levels and unfavorable functional outcome and death.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Serum IGF-1 levels in acute ischemic stroke patients and control group.
Mann–Whitney U-test. All data are medians and in-terquartile ranges (IQR). Significantly higher in stroke patients as compared to control cases (P<0.0001).
Figure 2
Figure 2. Correlation between serum IGF-1 levels and others predictors.
(a) Correlation between the serum IGF-1 levels and the National Institutes of Health Stroke Scale (NIHSS) score; (b) Correlation between serum IGF-1 levels and Hs-CRP;(c) Correlation between serum IGF-1 levels and infract volume;(d) Correlation between serum IGF-1 levels and HCY.
Figure 3
Figure 3. Serum IGF-1 levels in different groups. (a) Serum levels of Lp(a) in patients with favorable outcomes and unfavorable outcomes; (b) Serum levels of Lp(a) in survivor and non- survivor.
See this image and copyright information in PMC

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