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. 2014 Jul 28;12(28):5071-6.
doi: 10.1039/c4ob00682h.

Organocatalytic enantioselective allylic alkylation of MBH carbonates with β-keto esters

M Kamlar  1 , S Hybelbauerová, I Císařová, J Veselý
Affiliations

Organocatalytic enantioselective allylic alkylation of MBH carbonates with β-keto esters

M Kamlar et al. Org Biomol Chem. .

Abstract

The highly stereoselective allylic alkylation of Morita-Baylis-Hillman carbonates with β-ketoesters catalysed by β-ICD is described. The corresponding products containing two adjacent quaternary and tertiary carbon centers were obtained in good yields with high diastereoselectivity (up to 10 : 1 dr) and enantioselectivity (up to 95% ee).

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