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Randomized Controlled Trial
. 2014 Aug;58(8):4971-3.
doi: 10.1128/AAC.02889-14. Epub 2014 Jun 9.

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C Eziefula  1 , Helmi Pett  2 , Lynn Grignard  1 , Salome Opus  3 , Moses Kiggundu  3 , Moses R Kamya  4 , Shunmay Yeung  1 , Sarah G Staedke  1 , Teun Bousema  5 , Chris Drakeley  6
Affiliations
Randomized Controlled Trial

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C Eziefula et al. Antimicrob Agents Chemother. 2014 Aug.

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

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References

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