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Editorial
. 2014 Sep;64(3):461-2.
doi: 10.1161/HYPERTENSIONAHA.114.03477. Epub 2014 Jun 9.

Down but not out: an emerging role for the B-type endothelin receptor in placental ischemia-induced hypertension

Jeffrey S Gilbert  1 , Haley E Gillham  2 , Jean F Regal  2
Affiliations
Editorial

Down but not out: an emerging role for the B-type endothelin receptor in placental ischemia-induced hypertension

Jeffrey S Gilbert et al. Hypertension. 2014 Sep.
No abstract available

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Figures

Figure 1
Figure 1
Selected links between endothelin-1 (ET-1) and pathways potentially important in placental ischemia-induced hypertension and fetal growth restriction. Solid line depicts a known link. Dotted line depicts a negative regulator of ET receptor and dashed lines are clearly gaps in knowledge regarding connections with the endothelin system. Abbreviations: AT1-AA, autoantibodies to angiotensin II type 1 receptor; EC, endothelial cell; EMPs, endothelial cell microparticles; ER stress, endoplasmic reticulum stress; MMP-2, matrix metalloproteinase 2; NO, nitric oxide; RBF, renal blood flow; sFlt-1, soluble fms-like tyrosine kinase 1 or sVEGFR-1; STBMs, syncytiotrophoblast microparticles; SVR, systemic vascular resistance; VEGF, vascular endothelial growth factor.
See this image and copyright information in PMC

Comment on

References

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