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. 2014 May;18(5):310-4.
doi: 10.4103/0972-5229.132495.

Current concepts in combination antibiotic therapy for critically ill patients

Armin Ahmed  1 , Afzal Azim  1 , Mohan Gurjar  1 , Arvind Kumar Baronia  1
Affiliations

Current concepts in combination antibiotic therapy for critically ill patients

Armin Ahmed et al. Indian J Crit Care Med. 2014 May.

Abstract

Widespread emergence of multidrug resistant (MDR) bacterial pathogens is a problem of global dimension. MDR infections are difficult to treat and frequently associated with high mortality. More than one antibiotic is commonly used to treat such infections, but scientific evidence does not favor use of combination therapy in most cases. However, there are certain subgroups where combination therapy may be beneficial, e.g. sepsis due to carbapenem-resistant Enterobacteriaceae (CRE), bacteremic pneumococcal pneumonia, and patients with multiple organ failure. Well-designed prospective studies are needed to clearly define the role of combination therapy in these subgroups.

Keywords: Carbapenem-resistant enterobacteriaceae; Klebsiella pneumoniae carbapenemase; combination antibiotic therapy; sepsis.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Proposed algorithm for choosing antibiotic therapy for life threatening infection with MDR pathogen. MDR: Multidrug resistant
See this image and copyright information in PMC

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