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Review
. 2014 May 21;20(19):5700-7.
doi: 10.3748/wjg.v20.i19.5700.

miRNA polymorphisms and risk of gastric cancer in Asian population

Hai-Bing Hua  1 , Ting-Ting Yan  1 , Qing-Min Sun  1
Affiliations
Review

miRNA polymorphisms and risk of gastric cancer in Asian population

Hai-Bing Hua et al. World J Gastroenterol. .

Abstract

miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.

Keywords: Gastric cancer; Polymorphism; Risk; miRNA.

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Figures

Figure 1
Figure 1
miRNA biogenesis and processing.
See this image and copyright information in PMC

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