Selective autophagy goes exclusive
- PMID: 24914435
- DOI: 10.1038/ncb2961
Selective autophagy goes exclusive
Abstract
Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation.
Comment on
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Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.Nat Cell Biol. 2014 May;16(5):425-433. doi: 10.1038/ncb2935. Epub 2014 Apr 6. Nat Cell Biol. 2014. PMID: 24705553 Free PMC article.
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Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.Nat Cell Biol. 2014 May;16(5):415-24. doi: 10.1038/ncb2940. Epub 2014 Apr 20. Nat Cell Biol. 2014. PMID: 24747438 Free PMC article.
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