Directing traffic and autophagy in axonal transport
- PMID: 24914557
- PMCID: PMC4106466
- DOI: 10.1016/j.devcel.2014.05.016
Directing traffic and autophagy in axonal transport
Abstract
In this issue of Developmental Cell, Fu et al. (2014) address what determines persistent directional movement along microtubules of organelles capable of bidirectional transit. They show that retrograde axonal autophagosome transport is mediated by the scaffolding protein JIP1, which not only inhibits anterograde movement but may also promote autophagosome maturation.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
-
LC3 binding to the scaffolding protein JIP1 regulates processive dynein-driven transport of autophagosomes.Dev Cell. 2014 Jun 9;29(5):577-590. doi: 10.1016/j.devcel.2014.04.015. Dev Cell. 2014. PMID: 24914561 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
