Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jun 6;15(6):10150-68.
doi: 10.3390/ijms150610150.

BMP-functionalised coatings to promote osteogenesis for orthopaedic implants

Jianfeng Wang  1 , Jing Guo  2 , Jingsong Liu  3 , Limin Wei  4 , Gang Wu  5
Affiliations
Review

BMP-functionalised coatings to promote osteogenesis for orthopaedic implants

Jianfeng Wang et al. Int J Mol Sci. .

Abstract

The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic illustrating the signalling of bone morphogenetic proteins (BMPs) to induce osteogenic differentiation of mesenchymal stem cells or osteogenic cells. ALP: alkaline phosphatase; OCN: osteocalcin; Id: inhibitor of DNA binding 1; ERK: extracellular signal-related kinase.
Figure 2
Figure 2
Schematic illustrating the types of BMP/BMP-functionalised coatings on orthopaedic implants. (A) Direct adsorption; (B) Immobilisation of BMP through a chemical bond; (C) Adsorption of BMPs with a covering/barrier layer; (D) Incorporation of BMPs into a biomimetic/polymer/hybrid carrying layer; (E) Incorporation of BMPs into a polymer/hybrid carrier layer in combination with a covering/barrier layer; and (F) Incorporation of BMP genes into a polymer/hybrid carrier layer.
See this image and copyright information in PMC

References

    1. Claffey N., Clarke E., Polyzois I., Renvert S. Surgical treatment of peri-implantitis. J. Clin. Periodontol. 2008;35:316–332. doi: 10.1111/j.1600-051X.2008.01277.x. - DOI - PubMed
    1. Saito N., Takaoka K. New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials. 2003;24:2287–2293. doi: 10.1016/S0142-9612(03)00040-1. - DOI - PubMed
    1. Kretlow J.D., Mikos A.G. Review: Mineralization of synthetic polymer scaffolds for bone tissue engineering. Tissue Eng. 2007;13:927–938. doi: 10.1089/ten.2006.0394. - DOI - PubMed
    1. Silber J.S., Anderson D.G., Daffner S.D., Brislin B.T., Leland J.M., Hilibrand A.S., Vaccaro A.R., Albert T.J. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine. 2003;28:134–139. doi: 10.1097/00007632-200301150-00008. - DOI - PubMed
    1. Heary R.F., Schlenk R.P., Sacchieri T.A., Barone D., Brotea C. Persistent iliac crest donor site pain: Independent outcome assessment. Neurosurgery. 2002;50:510–516. - PubMed

Publication types

MeSH terms

LinkOut - more resources