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Review
. 2014 Jun 9:9:115.
doi: 10.1186/1746-1596-9-115.

Extranodal Rosai-Dorfman disease involving the right atrium in a 60-year-old male

Yalan Bi, Zhen Huo, Yunxiao Meng, Huanwen Wu, Jingbo Yan, Yuan Zhou, Xingrong Liu, Lan Song, Zhaohui Lu  1
Affiliations
Review

Extranodal Rosai-Dorfman disease involving the right atrium in a 60-year-old male

Yalan Bi et al. Diagn Pathol. .

Abstract

Rosai-Dorfman disease (RDD) involving the cardiovascular system is extremely rare; to our knowledge, there are only 9 cases in the literature. Here, a case of a 60-year-old male with RDD involving the right atrium is presented. A comprehensive literature review was undertaken to summarize the clinical and pathologic features of this disorder.

Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2143194139120169.

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Figures

Figure 1
Figure 1
A contrast-enhanced computed tomography image demonstrating an irregularly shaped, 25.0-mm right atrial mass extending along the right atrial free wall (white arrow); minor left-sided pleural effusion; slight pleural thickening of the right side; and diffuse pericardial effusion.
Figure 2
Figure 2
The tumor, showing histiocytic and chronic fibroinflammatory exudation, with areas of fibrosis (hematoxylin and eosin stain).
Figure 3
Figure 3
Histiocytes with large vesicular nuclei and abundant clear cytoplasm (hematoxylin and eosin stain).
Figure 4
Figure 4
Diffuse involvement of the myocardial interstitium and the myocardium (hematoxylin and eosin stain).
Figure 5
Figure 5
Histiocyte showing emperipolesis (hematoxylin and eosin stain).
Figure 6
Figure 6
Numerous histiocytes showing strong cytoplasmic immunohistochemical staining for S-100 (A). Numerous histiocytes showing strong cytoplasmic immunohistochemical staining for CD68 (B). Immunohistochemical staining showing CD1a negativity among histiocytes (C).
See this image and copyright information in PMC

References

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