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. 2013 Aug;1(4):236-41.
doi: 10.1177/2050640613495198.

Diagnosing early Barrett's neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue

Mate Knabe  1 , Christian Kurz  2 , Thorsten Knoll  2 , Thomas Velten  2 , Michael Vieth  3 , Hendrik Manner  1 , Christian Ell  1 , Oliver Pech  4
Affiliations

Diagnosing early Barrett's neoplasia and oesophageal squamous cell neoplasia by bioimpedance spectroscopy in human tissue

Mate Knabe et al. United European Gastroenterol J. 2013 Aug.

Abstract

Background: Detection of early oesophageal cancer in surrounding normal tissue can be challenging, but detection is essential to determine the subsequent treatment. Dysplastic tissue can be detected by using electrical impedance spectroscopy (EIS).

Objective: The aim of the present study was to evaluate the feasibility and value of EIS in the diagnosis of oesophageal neoplasia.

Methods: This prospective ex-vivo study included 23 patients with early oesophageal cancer (17 with Barrett's cancer and six with early squamous cell cancer). Immediately after endoscopic resection, the electrical properties of the resected specimens were investigated using a pencil probe (5 mm in diameter, frequency range from 100 Hz to 1 MHz). Punch biopsies were taken from the measured site in order to compare the results of EIS with histology.

Results: EIS was able to detect dysplastic oesophageal mucosa with a high rate of accuracy (82% in Barrett's oesophagus and 100% in squamous oesophagus) A total of 54 different sites in 26 tumours were evaluated.

Conclusions: EIS was able to differentiate reliably between non-neoplastic and neoplastic oesophageal mucosa. Using EIS, it might be possible to use it for targeted biopsies and to avoid unnecessary biopsies during cancer surveillance in future.

Keywords: Barrett’s carcinoma; Early oesophageal cancer; squamous cell cancer; surveillance; target biopsy.

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Figures

Figure 1.
Figure 1.
The experimental set up, with the impedance probe and a scale for pressure measurement underneath.
Figure 2.
Figure 2.
Impedance spectroscopy over 17 frequencies, comparing the histological results of Barrett’s epithelium with high-grade dysplasia/adenocarcinoma.
Figure 3.
Figure 3.
Impedance spectroscopy over 17 frequencies, comparing the histological results of squamous epithelium and different stages of squamous cell cancer.
See this image and copyright information in PMC

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