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. 2013 Aug;1(4):276-84.
doi: 10.1177/2050640613495196.

Application of international consensus diagnostic criteria to an Italian series of autoimmune pancreatitis

Tsukasa Ikeura  1 , Riccardo Manfredi  2 , Giuseppe Zamboni  2 , Riccardo Negrelli  2 , Paola Capelli  2 , Antonio Amodio  2 , Anna Caliò  2 , Giulia Colletta  2 , Armando Gabbrielli  2 , Luigi Benini  2 , Kazuichi Okazaki  1 , Italo Vantini  2 , Luca Frulloni  2
Affiliations

Application of international consensus diagnostic criteria to an Italian series of autoimmune pancreatitis

Tsukasa Ikeura et al. United European Gastroenterol J. 2013 Aug.

Abstract

Background: International consensus diagnostic criteria (ICDC) have been proposed to classify autoimmune pancreatitis (AIP) in type 1, type 2, or not otherwise specified.

Objective: Aim was to apply the ICDC to an Italian series of patients to evaluate the incidence and clinical profiles among different subtypes of AIP.

Methods: we re-evaluated and classified 92 patients diagnosed by Verona criteria, according to the ICDC.

Results: Out of 92 patients, 59 (64%) were diagnosed as type 1, 17 (18%) as type 2, and 15 (16%) as not otherwise specified according to the ICDC. A significant difference between type 1 and type 2 were found for age (54.5 ± 14.5 vs. 34.4 ± 13.9 respectively; p < 0.0001), male sex (76 vs. 47%; p = 0.007), jaundice (66 vs. 18%; p = 0.002) and acute pancreatitis (9 vs. 47%; p < 0.0001), elevated serum IgG4 levels (85 vs. 7%; p < 0.0001), inflammatory bowel disease (8 vs. 82%; < 0.0001), and relapse of the disease (34 vs. 6%; p = 0.058). Imaging and response to steroids in the not-otherwise-specified group were similar to type 1 and 2.

Conclusions: Type 1 has a different clinical profile from type 2 autoimmune pancreatitis. The not-otherwise-specified group has peculiar clinical features which are shared both with type 1 or type 2 groups.

Keywords: Autoimmunity; diagnosis; imaging; pancreatic diseases; pathology.

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Figures

Figure 1.
Figure 1.
Flow chart of diagnosis according to the ICDC algorithm for type 1 AIP. *Level 2D is counted as level 1 in this setting.
Figure 2.
Figure 2.
Flow chart of diagnosis according to the ICDC algorithm for type 2 AIP and AIP-NOS.
See this image and copyright information in PMC

References

    1. Yoshida K, Toki F, Takeuchi T, et al. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci 1995; 40: 1561–1568 - PubMed
    1. Finkelberg DL, Sahani D, Deshpande V, et al. Autoimmune pancreatitis. N Engl J Med 2006; 355: 2670–2676 - PubMed
    1. Frulloni L, Scattolini C, Falconi M, et al. Autoimmune pancreatitis: differences between the focal and diffuse forms in 87 patients. Am J Gastroenterol 2009; 104: 2288–2294 - PubMed
    1. Okazaki K, Uchida K, Koyabu M, et al. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J Gastroenterol 2011; 46: 277–288 - PubMed
    1. Manfredi R, Frulloni L, Mantovani W, et al. Autoimmune pancreatitis: pancreatic and extrapancreatic MR imaging-MR cholangiopancreatography findings at diagnosis, after steroid therapy, and at recurrence. Radiology 2011; 260: 428–436 - PubMed