doi: 10.1021/co500001u.
Epub 2014 Jun 20.
One-pot synthesis of benzo[4,5]imidazo[1,2-a]quinazoline derivatives via facile transition-metal-free tandem process
Affiliations
- PMID: 24919956
- DOI: 10.1021/co500001u
Item in Clipboard
One-pot synthesis of benzo[4,5]imidazo[1,2-a]quinazoline derivatives via facile transition-metal-free tandem process
ACS Comb Sci.
.
Abstract
A one-pot transition metal-free method for synthesizing benzo[4,5]imidazo[1,2-a]quinazoline and imidazo[1,2-a]quinazoline derivatives has been developed. The approach is widely applicable to 2-fluoro-, 2-chloro-, 2-bromo- and 2-nitro-substituted aryl aldehyde and ketone substrates. The fluorescence properties of target compounds were studied.
Similar articles
-
CuI-catalyzed C-N bond formation and cleavage for the synthesis of benzimidazo[1,2-a]quinazoline derivatives.J Org Chem. 2014 Jun 20;79(12):5847-51. doi: 10.1021/jo5007398. Epub 2014 Jun 10. J Org Chem. 2014. PMID: 24885515
-
Synthesis of pyrazolo[1,5-c]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with carbonyl compounds and aqueous ammonia.J Org Chem. 2013 Apr 5;78(7):3262-70. doi: 10.1021/jo4001756. Epub 2013 Mar 21. J Org Chem. 2013. PMID: 23485094
-
Copper-Catalyzed Domino Three-Component Approach for the Assembly of 2-Aminated Benzimidazoles and Quinazolines.J Org Chem. 2015 Jun 19;80(12):6102-8. doi: 10.1021/acs.joc.5b00614. Epub 2015 Jun 9. J Org Chem. 2015. PMID: 26056863
-
Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures.Mini Rev Med Chem. 2006 Jan;6(1):71-89. doi: 10.2174/138955706775197839. Mini Rev Med Chem. 2006. PMID: 16457633 Review.
-
Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives.Molecules. 2024 May 16;29(10):2353. doi: 10.3390/molecules29102353. Molecules. 2024. PMID: 38792215 Free PMC article. Review.
Cited by
-
Aminoazole-Based Diversity-Oriented Synthesis of Heterocycles.Front Chem. 2018 Nov 13;6:527. doi: 10.3389/fchem.2018.00527. eCollection 2018. Front Chem. 2018. PMID: 30555815 Free PMC article. Review.
-
Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use.Chem Heterocycl Compd (N Y). 2021;57(4):383-409. doi: 10.1007/s10593-021-02916-4. Epub 2021 May 15. Chem Heterocycl Compd (N Y). 2021. PMID: 34024913 Free PMC article.
-
Synthesis of Pyrimidine- and Quinazoline-Fused Benzimidazole-4,7-diones Using Combinatorial Cyclocondensation and Oxidation.ACS Omega. 2018 Dec 17;3(12):17456-17465. doi: 10.1021/acsomega.8b02755. eCollection 2018 Dec 31. ACS Omega. 2018. PMID: 31458351 Free PMC article.
-
Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-a] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System.J Org Chem. 2025 Mar 21;90(11):4018-4027. doi: 10.1021/acs.joc.4c03123. Epub 2025 Mar 6. J Org Chem. 2025. PMID: 40051158 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
