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Review
. 2014 May 28:9:2713-25.
doi: 10.2147/IJN.S55943. eCollection 2014.

Multifunctional materials for bone cancer treatment

Catarina Marques  1 , José M F Ferreira  1 , Ecaterina Andronescu  2 , Denisa Ficai  2 , Maria Sonmez  3 , Anton Ficai  2
Affiliations
Review

Multifunctional materials for bone cancer treatment

Catarina Marques et al. Int J Nanomedicine. .

Abstract

The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen-hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.

Keywords: bone graft; cancer; collagen; cytostatics; magnetite; silver.

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Figures

Figure 1
Figure 1
Collagen (COLL) forms and their COLL/hydroxyapatite (HA) composite (nano)materials. Notes: Reprinted from Chem Eng J.160. Ficai A, Andronescu E, Voicu G, et al. Self assembled collagen/hydroxyapatite composite materials. 794–800. Copyright (2010), with permission from Elsevier. Reprinted from Mater Lett. 64. Ficai A, Andronescu E, Trandafir V, Ghitulica C, Voicu G. Collagen/hydroxyapatite composite obtained by electric field orientation. 541–544. Copyright (2010), with permission from Elsevier. Adapted from Golub LM. Special Issue: Clinical Applications of Non-Antbacterial Tetracyclines Introduction. Pharmacol Res. 2011;63:99–101.
Figure 2
Figure 2
Applications of magnetite and magnetite-based materials. Abbreviation: MRI, magnetic resonance imaging.
Figure 3
Figure 3
Schematic representation of bone cancer treatment by combined therapy (surgery and hyperthermia). Note: With kind permission from Springer Science+Business Media: J Mater Sci—Mater M., Synthesis and characterization of collagen/hydroxyapatite:magnetite composite material for bone cancer treatment. 21, 2010, 2237–2242, Andronescu E, Ficai M, Voicu G, Ficai D, Maganu M, Ficai A, figure 2.
Figure 4
Figure 4
Hyperthermia versus content of magnetite. Note: Data from Andronescu E et al.
See this image and copyright information in PMC

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