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Review
. 2014 May 23:6:537-45.
doi: 10.2147/IJWH.S40894. eCollection 2014.

Clinical epidemiology of epithelial ovarian cancer in the UK

Konstantinos Doufekas  1 , Adeola Olaitan  1
Affiliations
Review

Clinical epidemiology of epithelial ovarian cancer in the UK

Konstantinos Doufekas et al. Int J Womens Health. .

Abstract

Epithelial ovarian cancer is the fifth commonest cancer among women and the leading cause of gynecological cancer death in the UK. Most women present with advanced disease, mainly because the nonspecific nature of the symptoms lead to diagnostic delays. Recent data have shown a fall in ovarian cancer mortality rates in the UK, but rates are still higher when compared to other European countries or the USA. In addition, surgeons in the UK achieve on average lower optimal surgical cytoreduction rates in patients with advanced ovarian cancer. Despite a wealth of information on epidemiological risk factors, the pathogenesis of epithelial ovarian cancer remains largely unknown. This review presents the most recent data on incidence, mortality, and survival for epithelial ovarian cancer in the UK. Time trends, trends by age, international comparisons, and regional variation in incidence, survival, and mortality are presented within the context of a major reorganization of cancer services that took place in the UK over 10 years ago. Centralization of cancer services has meant that women with ovarian cancer receive treatment in specialist Cancer Centers.

Keywords: UK; cancer; epidemiology; incidence; ovarian; survival.

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References

    1. Berrino F, De Angelis R, Sant M, et al. EUROCARE Working group Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995–1999: results of the EUROCARE-4 study. Lancet Oncol. 2007;8(9):773–783. - PubMed
    1. Ferlay J, Bray F, Pisani P, Parkin DM. Cancer Incidence, Mortality and Prevalence Worldwide. IARC Cancer Base No 5, Version 2.0. Lyon: IARC Press; 2004. GLOBOCAN 2002.
    1. Ovarian cancer statistics [webpage on the Internet] Oxford: Cancer Research UK; 2013. [Accessed January 10, 2014]. [updated Jan 2013]. Available from: http://www.cancerresearchuk.org/cancer-info/cancerstats/types/ovary/
    1. Targeted Therapies for the Management of Ovarian Cancer (Scientific Impact Paper No 12) [webpage on the Internet] London: Royal College of Obstetricians and Gynaecologists; 2013. [Accessed January 10, 2014]. Available from: http://www.rcog.org.uk/womens-health/clinical-guidance/targeted-therapie....
    1. Overview of Ovarian Cancer in England: Incidence, Mortality and Survival (Nov 2012) [webpage on the Internet] London: National Cancer Intelligence Network; [Accessed January 10, 2014]. Available from: http://www.ncin.org.uk/cancer_type_and_topic_specific_work/cancer_type_s....

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