Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 May;76(5):211-7.
doi: 10.4046/trd.2014.76.5.211. Epub 2014 May 29.

Malignant pleural effusion: medical approaches for diagnosis and management

Affiliations
Review

Malignant pleural effusion: medical approaches for diagnosis and management

Hae-Seong Nam. Tuberc Respir Dis (Seoul). 2014 May.

Abstract

Malignant pleural effusions (MPEs) are the second leading cause of exudative pleural effusions after parapneumonic effusions. In the vast majority of cases, a MPE signifies incurable disease associated with high morbidity and mortality. Considerable advances have been made for the diagnosis of MPEs, through the development of improved methods in the specialized cytological and imaging studies. The cytological or histological confirmation of malignant cells is currently important in establishing a diagnosis. Furthermore, despite major advancements in cancer treatment for the past two decades, management of MPE remains palliative. This article presents a comprehensive review of the medical approaches for diagnosis and management of MPE.

Keywords: Diagnosis; Disease Management; Pleural Effusion, Malignant.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Algorithm for the management of malignant pleural effusion. Adopted from Nam and Ryu, with permission from The Korean Association of Internal Medicine.

References

    1. Thomas JM, Musani AI. Malignant pleural effusions: a review. Clin Chest Med. 2013;34:459–471. - PubMed
    1. Light RW. Pleural diseases. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2013.
    1. Heffner JE, Klein JS. Recent advances in the diagnosis and management of malignant pleural effusions. Mayo Clin Proc. 2008;83:235–250. - PubMed
    1. Heffner JE, Nietert PJ, Barbieri C. Pleural fluid pH as a predictor of survival for patients with malignant pleural effusions. Chest. 2000;117:79–86. - PubMed
    1. Bielsa S, Salud A, Martinez M, Esquerda A, Martin A, Rodriguez-Panadero F, et al. Prognostic significance of pleural fluid data in patients with malignant effusion. Eur J Intern Med. 2008;19:334–339. - PubMed