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Comparative Study
. 2014 Jul 29;111(3):619-22.
doi: 10.1038/bjc.2014.301. Epub 2014 Jun 12.

Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast

A C Chen  1 , A C Paulino  2 , M R Schwartz  3 , A A Rodriguez  4 , B L Bass  5 , J C Chang  4 , B S Teh  2
Affiliations
Comparative Study

Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast

A C Chen et al. Br J Cancer. .

Abstract

Background: Invasive micropapillary carcinoma (IMPC) is a variant of breast carcinoma with a higher propensity for lymph node metastases compared with invasive ductal carcinoma (IDC).

Methods: Retrospective analysis of 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology and End RESULTS database comparing disease-specific survival (DSS) and overall survival (OS) between IMPC and IDC.

Results: A higher percentage of IMPC cases (52.0%) had nodal metastases compared with IDC cases (34.6%). The 5-year DSS and OS for IMPC was 91.8% and 82.9%, respectively compared with 88.6% and 80.5% for IDC, respectively. For both IMPC and IDC, oestrogen-receptor positivity was associated with better survival, while having four or more positive lymph nodes or larger tumour size correlated with worse survival. Radiotherapy provided a survival benefit for both histological types.

Conclusions: Despite IMPC's higher propensity for lymph node metastasis, IMPC has DSS and OS that compare favourably with IDC.

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Figures

Figure 1
Figure 1
Disease-specific (A) and overall survival (B) by histology; Abbreviations: HR=hazard ratio; IDC=invasive ductal carcinoma; IMPC=invasive micropapillary carcinoma.
Figure 2
Figure 2
Degree of lymph node involvement affects disease-specific (A) and overall survival (B) in invasive micropapillary carcinoma; Abbreviation: HR, hazard ratio.
See this image and copyright information in PMC

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References

    1. Adrada B, Arribas E, Gilcrease M, Yang WT. Invasive micropapillary carcinoma of the breast: mammographic, sonographic, and mri features. AJR Am J Roentgenol. 2009;193 (1:W58–W63. - PubMed
    1. Chen AC, Paulino AC, Schwartz MR, Rodriguez AA, Bass BL, Chang JC, Teh BS. Prognostic markers for invasive micropapillary carcinoma of the breast: a population-based analysis. Clin Breast Cancer. 2013;13 (2:133–139. - PubMed
    1. Chen L, Fan Y, Lang R-G, Guo X-J, Sun Y-L, Cui L-F, Liu F-F, Wei J, Zhang X-M, Fu L. Breast carcinoma with micropapillary features: clinicopathologic study and long-term follow-up of 100 cases. Int J Surg Pathol. 2008;16 (2:155–163. - PubMed
    1. Fisher ER, Palekar AS, Redmond C, Barton B, Fisher B. Pathologic findings from the national surgical adjuvant breast project (protocol no. 4). vi. invasive papillary cancer. Am J Clin Pathol. 1980;73 (3:313–322. - PubMed
    1. Gokce H, Durak MG, Akin MM, Canda T, Balci P, Ellidokuz H, Demirkan B, Gorken IB, Sevinc AI, Kocdor MA, Saydam S, Harmancioglu O. Invasive micropapillary carcinoma of the breast: a clinicopathologic study of 103 cases of an unusual and highly aggressive variant of breast carcinoma. Breast J. 2013;19 (4:374–381. - PubMed

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