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Comparative Study
. 2014 Jul 29;111(3):619-22.
doi: 10.1038/bjc.2014.301. Epub 2014 Jun 12.

Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast

A C Chen  1 , A C Paulino  2 , M R Schwartz  3 , A A Rodriguez  4 , B L Bass  5 , J C Chang  4 , B S Teh  2
Affiliations
Comparative Study

Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast

A C Chen et al. Br J Cancer. .

Abstract

Background: Invasive micropapillary carcinoma (IMPC) is a variant of breast carcinoma with a higher propensity for lymph node metastases compared with invasive ductal carcinoma (IDC).

Methods: Retrospective analysis of 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology and End RESULTS database comparing disease-specific survival (DSS) and overall survival (OS) between IMPC and IDC.

Results: A higher percentage of IMPC cases (52.0%) had nodal metastases compared with IDC cases (34.6%). The 5-year DSS and OS for IMPC was 91.8% and 82.9%, respectively compared with 88.6% and 80.5% for IDC, respectively. For both IMPC and IDC, oestrogen-receptor positivity was associated with better survival, while having four or more positive lymph nodes or larger tumour size correlated with worse survival. Radiotherapy provided a survival benefit for both histological types.

Conclusions: Despite IMPC's higher propensity for lymph node metastasis, IMPC has DSS and OS that compare favourably with IDC.

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Figures

Figure 1
Figure 1
Disease-specific (A) and overall survival (B) by histology; Abbreviations: HR=hazard ratio; IDC=invasive ductal carcinoma; IMPC=invasive micropapillary carcinoma.
Figure 2
Figure 2
Degree of lymph node involvement affects disease-specific (A) and overall survival (B) in invasive micropapillary carcinoma; Abbreviation: HR, hazard ratio.
See this image and copyright information in PMC

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