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. 2014 Sep:91:92-6.
doi: 10.1016/j.apradiso.2014.05.011. Epub 2014 May 24.

⁶⁸Ge content quality control of ⁶⁸Ge/⁶⁸Ga-generator eluates and ⁶⁸Ga radiopharmaceuticals--a protocol for determining the ⁶⁸Ge content using thin-layer chromatography

Elisabeth Eppard  1 , Natalia S Loktionova  1 , Frank Rösch  2
Affiliations

⁶⁸Ge content quality control of ⁶⁸Ge/⁶⁸Ga-generator eluates and ⁶⁸Ga radiopharmaceuticals--a protocol for determining the ⁶⁸Ge content using thin-layer chromatography

Elisabeth Eppard et al. Appl Radiat Isot. 2014 Sep.

Abstract

(68)Ge breakthrough from a (68)Ge/(68)Ga-generator appears to be one of the most critical parameters for the routine clinical application of this generator and (68)Ga-radiopharmaceuticals. We report a TLC-based (thin-layer chromatography) protocol which allows the (68)Ge breakthrough of a generator to be determined within 1 h post-initial elution. The protocol can also be adapted to allow the (68)Ge content of a (68)Ga-radiopharmaceutical preparation to be determined prior to in vivo application.

Keywords: (68)Ge/(68)Ga-generator; Breakthrough; Ga-68-DOTATOC; Ga-68-radiopharmaceutical; Separation; TLC.

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