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Comparative Study
. 2014 Aug;134(2):267-73.
doi: 10.1016/j.ygyno.2014.06.002. Epub 2014 Jun 10.

A nationwide study of serous "borderline" ovarian tumors in Denmark 1978-2002: centralized pathology review and overall survival compared with the general population

Charlotte Gerd Hannibal  1 , Russell Vang  2 , Jette Junge  3 , Kirsten Frederiksen  1 , Anette Kjaerbye-Thygesen  1 , Klaus Kaae Andersen  1 , Ann Tabor  4 , Robert J Kurman  5 , Susanne K Kjaer  6
Affiliations
Comparative Study

A nationwide study of serous "borderline" ovarian tumors in Denmark 1978-2002: centralized pathology review and overall survival compared with the general population

Charlotte Gerd Hannibal et al. Gynecol Oncol. 2014 Aug.

Abstract

Objective: To describe the study population and estimate overall survival of women with a serous "borderline" ovarian tumor (SBT) in Denmark over 25 years relative to the general population.

Methods: The Danish Pathology Data Bank and the Danish Cancer Registry were used to identify 1487 women diagnosed with SBTs from 1978 to 2002. The histologic slides were collected from Danish pathology departments and reviewed by expert pathologists and classified as SBT/atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Associated implants were classified as noninvasive or invasive. Medical records were collected from hospital departments and reviewed. Data were analyzed using Kaplan-Meier and relative survival was estimated with follow-up through September 2, 2013.

Results: A cohort of 1042 women with a confirmed SBT diagnosis was identified. Women with stage I had an overall survival similar to the overall survival expected from the general population (p=0.3), whereas women with advanced stage disease had a poorer one (p<0.0001). This was evident both in women with noninvasive (p<0.0001) and invasive implants (p<0.0001). Only among women with advanced stage, overall survival of women with SBT/APST (p<0.0001) and noninvasive LGSC (p<0.0001) was poorer than expected from the general population.

Conclusions: To date this is the largest nationwide cohort of SBTs where all tumors have been verified by expert pathologists. Only in women with advanced stage SBT, overall survival is poorer than in the general population which applies both to women with noninvasive and invasive implants as well as to women with SBT/APST and noninvasive LGSC.

Keywords: Centralized pathology review; Long-term follow-up; Population-based; Relative survival; Serous “borderline” ovarian tumors.

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Conflict of interest statement

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Design of the study.
Fig. 2
Fig. 2
Overall survival of women with a serous borderline ovarian tumor (SBT) in Denmark 1978–2002 relative to the general population of same age in the same calendar year.
Fig. 3
Fig. 3
Overall survival of women with a serous borderline ovarian tumor (SBT) in Denmark 1978–2002 relative to the general population of same age in the same calendar year with regard to stage at diagnosis (I and II–IV).
See this image and copyright information in PMC

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