Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2014 Sep;24(9):956-62.
doi: 10.1016/j.numecd.2014.03.009. Epub 2014 Apr 26.

Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

C L Falconer  1 , A R Cooper  2 , J P Walhin  3 , D Thompson  3 , A S Page  4 , T J Peters  5 , A A Montgomery  6 , D J Sharp  7 , C M Dayan  8 , R C Andrews  5
Affiliations
Randomized Controlled Trial

Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes

C L Falconer et al. Nutr Metab Cardiovasc Dis. 2014 Sep.

Abstract

Background and aims: We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes.

Methods and results: We studied 285 adults (184 men, 101 women, mean age 59.0 ± 9.7) who had been recruited to the Early ACTivity in Diabetes (Early ACTID) randomised controlled trial. C-reactive protein (CRP), adiponectin, soluble intracellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), and accelerometer-determined sedentary time and moderate-vigorous physical activity (MVPA) were measured at baseline and after six-months. Linear regression analysis was used to investigate the independent cross-sectional and longitudinal associations of sedentary time with markers of inflammation. At baseline, associations between sedentary time and IL-6 were observed in men and women, an association that was attenuated following adjustment for waist circumference. After 6 months of follow-up, sedentary time was reduced by 0.4 ± 1.2 h per day in women, with the change in sedentary time predicting CRP at follow-up. Every hour decrease in sedentary time between baseline and six-months was associated with 24% (1, 48) lower CRP. No changes in sedentary time between baseline and 6 months were seen in men.

Conclusions: Higher sedentary time is associated with IL-6 in men and women with type 2 diabetes, and reducing sedentary time is associated with improved levels of CRP in women. Interventions to reduce sedentary time may help to reduce inflammation in women with type 2 diabetes.

Keywords: Breaks in sedentary time; Inflammation; Sedentary time; Type 2 diabetes.

PubMed Disclaimer

References

    1. Chen L., Magliano D.J., Zimmet P.Z. The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives. Nat Rev Endocrinol. 2011;8(4):228–236. - PubMed
    1. Monesi L., Tettamanti M., Cortesi L., Baviera M., Marzona I., Avanzini F. Elevated risk of death and major cardiovascular events in subjects with newly diagnosed diabetes: findings from an administrative database. Nutrition, metabolism, and cardiovascular diseases. Nutr Metab Cardiovasc Dis. 2014;24(3):263–270. - PubMed
    1. Williams M., Nadler J. Inflammatory mechanisms of diabetic complications. Curr Diab Rep. 2007/06/01;7(3):242–248. [in English] - PubMed
    1. Pearson T.A., Mensah G.A., Alexander R.W., Anderson J.L., Cannon R.O., Criqui M. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. January 28, 2003;107(3):499–511. - PubMed
    1. Yu H.I., Sheu W.H.H., Song Y.M., Liu H.C., Lee W.J., Chen Y.T. C-reactive protein and risk factors for peripheral vascular disease in subjects with type 2 diabetes mellitus. Diabet Med. 2004;21(4):336–341. - PubMed

Publication types