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Comment
. 2014 Jun 13;344(6189):1237.
doi: 10.1126/science.1254082.

Virology. Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Francis V Chisari  1 , William S Mason  2 , Christoph Seeger  2
Affiliations
Comment

Virology. Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Francis V Chisari et al. Science. .

Abstract

Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 million patients who are chronically infected by HBV.

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Comment on

  • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
    Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. Lucifora J, et al. Science. 2014 Mar 14;343(6176):1221-8. doi: 10.1126/science.1243462. Epub 2014 Feb 20. Science. 2014. PMID: 24557838 Free PMC article.

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