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. 1989 Mar;63(3):1212-22.
doi: 10.1128/JVI.63.3.1212-1222.1989.

Physical properties of the Creutzfeldt-Jakob disease agent

T K Sklaviadis  1 , L Manuelidis, E E Manuelidis
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Physical properties of the Creutzfeldt-Jakob disease agent

T K Sklaviadis et al. J Virol. 1989 Mar.

Abstract

In this report, we present the first physical characterization of the Creutzfeld-Jakob disease agent. Preparations with high yields of infectivity (assayed infectious units) were obtained by a novel, gentle procedure in which initially sedimenting Gp34 ("prion" protein) was disaggregated by a variety of criteria with no subsequent loss of infectivity. Studies with this preparation indicate that most of the Creutzfeld-Jakob disease agent has both a viruslike size and density. In velocity sedimentation and isopycnic sucrose gradients, infectivity comigrated with nucleic acid-protein complexes of appreciable size.

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