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. 2014 Jun;7(6):1521-1524.
doi: 10.3892/etm.2014.1658. Epub 2014 Apr 2.

Malignant lymphoma of the ureter: A case report and literature review

Bei-Wen Ni  1 , Lu Zhong  1 , Ting Wang  1 , Fang-Yuan Chen  1
Affiliations

Malignant lymphoma of the ureter: A case report and literature review

Bei-Wen Ni et al. Exp Ther Med. 2014 Jun.

Abstract

A 38-year-old male was admitted to Renji Hospital (Shanghai, China) with the major complaint of back pain due to left hydronephrosis. Imaging analysis revealed an area of nodular soft-tissue density in the left ureteral wall. The patient's left kidney was non-functional. Thus, a left nephroureterectomy was performed for the purpose of pathological diagnosis, and histopathological examination revealed follicular lymphoma. The patient received R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) every three weeks. Following six courses of chemotherapy, positron emission tomography-computed tomography revealed that the patient was in complete remission. From this case we showed that in cases where a partial ureteral stenosis with ureteral wall thickening was observed by imaging analysis, further histological examination of tissue samples should be assigned as soon as possible.

Keywords: lymphoma; malignant; ureter.

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Figures

Figure 1
Figure 1
Left hydronephrosis and stenosis of the left ureter as shown by magnetic resonance urography.
Figure 2
Figure 2
PET-CT scans revealed a nodular soft-tissue density area in the wall of the left-middle ureter at the L3 level, paraaortic and iliac lymphadenopathy and increased FDG uptake in the sternum and right ilium. PET-CT, positron emission tomography-computed tomography; FDG, fludeoxyglucose.
Figure 3
Figure 3
Atypical lymphocytes from follicular nodules, as shown by HE staining at a magnification of (A) ×100 and (B) ×400. HE, hematoxylin and eosin.
Figure 4
Figure 4
Immumohistochemical staining revealed positive reactions for (A) Bcl-2, (B) CD20, (C) CD21, (D) Ki-67, (E) CD79-alpha and (F) CD23 in the nodular soft-tissue in the wall of the left-middle ureter (magnification, ×100).
See this image and copyright information in PMC

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