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. 2014 Mar;19(1):49-52.
doi: 10.6065/apem.2014.19.1.49. Epub 2014 Mar 31.

Glycogenic hepatopathy in a Korean girl with poorly controlled type 1 diabetes mellitus

Hwal Rim Jeong  1 , Young Seok Shim  1 , Young Bae Kim  2 , Hae Sang Lee  1 , Jin Soon Hwang  1
Affiliations

Glycogenic hepatopathy in a Korean girl with poorly controlled type 1 diabetes mellitus

Hwal Rim Jeong et al. Ann Pediatr Endocrinol Metab. 2014 Mar.

Abstract

Glycogenic hepatopathy (GH) is a rare complication of type 1 diabetes mellitus. We report the case of a 13-year-old diabetic female with poorly controlled blood sugar levels who presented with abdominal pain and distention 1 month in duration. She exhibited tender hepatomegaly, an elevated lipid profile, and elevated serum transaminase levels. Her liver histology was consistent with GH. The pathophysiology and/or underlying genetic background of GH remains unclear. The optimum treatment for GH is optimal glycemic control, and the prognosis is favorable. Clinicians should be aware of the possibility of GH and observe the clinical response to optimal glycemic control prior to invasive investigation.

Keywords: Glycogenic hepaptopathy; Hepatomegaly; Type 1 diabetes mellitus.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Abdominal computed tomography revealed hepatomegaly and marked liver attenuation.
Fig. 2
Fig. 2
(A) Intact lobular architecture; swollen hepatocytes exhibited pyknotic nuclei and intranuclear glycogen granules (X200). (B) Periodic acid-Schiff staining revealed abundant accumulation of cytoplasmic glycogen (×400). (C) Diastase removed all glycogen (×400).
See this image and copyright information in PMC

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