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Randomized Controlled Trial
. 2014 Sep;8(3):403-6.
doi: 10.1007/s11682-014-9309-9.

A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial

Ekaterina Dobryakova  1 , Glenn R Wylie, John DeLuca, Nancy D Chiaravalloti
Affiliations
Randomized Controlled Trial

A pilot study examining functional brain activity 6 months after memory retraining in MS: the MEMREHAB trial

Ekaterina Dobryakova et al. Brain Imaging Behav. 2014 Sep.

Abstract

Cognitive impairment in individuals with multiple sclerosis (MS) is now well recognized. One of the most common cognitive deficits is found in memory functioning, largely due to impaired acquisition. We examined functional brain activity 6 months after memory retraining in individuals with MS. The current report presents long term follow-up results from a randomized clinical trial on a memory rehabilitation protocol known as the modified Story Memory Technique. Behavioral memory performance and brain activity of all participants were evaluated at baseline, immediately after treatment, and 6 months after treatment. Results revealed that previously observed increases in patterns of cerebral activation during learning immediately after memory training were maintained 6 months post training.

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Conflict of interest statement

The authors have no conflicts of interest to report.

Figures

Figure 1
Figure 1
A. Medial temporal lobe, the insula and the visual cortex areas showing a main effect of treatment, with treatment group showing more activation than the placebo control group. B. Mean parameter estimates from the left medial temporal lobe, showing the main effect of group. Other three regions showed the same pattern of results. Error bars represent standard error of the mean.
Figure 1
Figure 1
A. Medial temporal lobe, the insula and the visual cortex areas showing a main effect of treatment, with treatment group showing more activation than the placebo control group. B. Mean parameter estimates from the left medial temporal lobe, showing the main effect of group. Other three regions showed the same pattern of results. Error bars represent standard error of the mean.
See this image and copyright information in PMC

References

    1. Allen DN, Goldstein G, Heyman RA, Rondinelli T. Teaching memory strategies to persons with multiple sclerosis. Journal of Rehabilitation Research and Development. 1998;35(4):405–10. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10220218. - PubMed
    1. Cerasa A, Gioia MC, Valentino P, Nisticò R, Chiriaco C, Pirritano D, Quattrone A. Computer-assisted cognitive rehabilitation of attention deficits for multiple sclerosis: a randomized trial with FMRI correlates. Neurorehabilitation and Neural Repair. 2013;27(4):284–95. doi: 10.1177/1545968312465194. - DOI - PubMed
    1. Chiaravalloti N, Balzano J, Moore NB, Deluca J. The Open-Trial Selective Reminding Test (OT-SRT) as a Tool for the Assessment of Learning and Memory. The Clinical Neuropsychologist. 2009;23:231–254. doi: 10.1080/13854040802121158. - DOI - PubMed
    1. Chiaravalloti N, Moore NB, Nikelshpur OM, Deluca J. An RCT to treat learning impairment in multiple sclerosis: The MEMREHAB trial. Neurology. 2013 doi: 10.1212/01.wnl.0000437295.97946.a8. - DOI - PMC - PubMed
    1. Chiaravalloti N, Wylie G, Leavitt V, Deluca J. Increased cerebral activation after behavioral treatment for memory deficits in MS. Journal of Neurology. 2012;259(7):1337–46. doi: 10.1007/s00415-011-6353-x. - DOI - PubMed

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