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Review
. 2014 Oct;164(4):284-92.
doi: 10.1016/j.trsl.2014.05.008. Epub 2014 May 24.

Adipose tissue changes in obesity and the impact on metabolic function

Susan Sam  1 , Theodore Mazzone  2
Affiliations
Review

Adipose tissue changes in obesity and the impact on metabolic function

Susan Sam et al. Transl Res. 2014 Oct.

Abstract

Obesity is associated with adverse alterations in adipose tissue that predispose to metabolic dysregulation. These adverse alterations include accumulation of inflammatory macrophages leading to the activation of inflammation pathways, reduction in lipid turnover, and deposition of fat in ectopic locations. These alterations are precursors to the development of insulin resistance and metabolic dysfunction.

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