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. 2014 Aug;165(2):404-407.e1.
doi: 10.1016/j.jpeds.2014.04.046. Epub 2014 Jun 11.

Clinical and neuroimaging findings in neonatal herpes simplex virus infection

Monika Bajaj  1 , Swati Mody  2 , Girija Natarajan  3
Affiliations

Clinical and neuroimaging findings in neonatal herpes simplex virus infection

Monika Bajaj et al. J Pediatr. 2014 Aug.

Abstract

In a retrospective review of infants with neonatal herpes simplex virus disease (n=29), we found bilateral multilobar (n=8), pontine (n=3), thalamic (n=6), and internal capsule and corticospinal tract (n=5) involvement on magnetic resonance imaging (MRI). Diffusion-weighted imaging (n=6) performed early revealed additional involvement than detected by conventional MRI. Neurodevelopmental sequelae were correlated with MRI abnormalities. Our findings demonstrate that MRI, including diffusion-weighted imaging, is a valuable prognostic adjunct in neonatal herpes simplex virus disease.

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