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. 2014 Oct;128(4):605-7.
doi: 10.1007/s00401-014-1307-x. Epub 2014 Jun 15.

Subventricular spread of diffuse intrinsic pontine glioma

Viola Caretti  1 , Marianna Bugiani, Morgan Freret, Pepijn Schellen, Marc Jansen, Dannis van Vuurden, Gertjan Kaspers, Paul G Fisher, Esther Hulleman, Pieter Wesseling, Hannes Vogel, Michelle Monje
Affiliations

Subventricular spread of diffuse intrinsic pontine glioma

Viola Caretti et al. Acta Neuropathol. 2014 Oct.
No abstract available

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Extent of spread in DIPG. a Neuroanatomical sites and frequency of tumor invasion. Numbers indicate the percentage of cases that exhibit tumor invasion at the indicated anatomical location. The size of the circles marking each anatomical site (color key to the left) illustrates the frequency. CC corpus callosum, infrat. L.M. infratentorial leptomeninges, Suprat. L.M. supratentorial leptomeninges. photomicrographs illustrating b Olig2 + tumor cells infiltrating the cerebellum, c tumor infiltrating the substantia nigra in the midbrain (H&E), d tumor infiltrating the thalamus (H&E), e leptomeningeal spread affecting the temporal lobe (H&E), f tumor in the frontal cortex (H&E) and g Olig2 + tumor cells in the frontal lobe. Immunostains DAB with hematoxylin counterstain. Scale bars 100 μm (b–d, f), 1 mm (e) and 50 μm (g)
Fig. 2
Fig. 2
Invasion of the subventricular zone in DIPG (a). MRI images illustrating enhancing lesions (T1 post gadolinium, left image) at the frontal horns of the lateral ventricles with associated edema (FLAIR, right image) in case SU-DIPG-XIII. b H&E (left) and nestin immunostaining (right) of DIPG tumor at the frontal horn of the lateral ventricle in case SU-DIPG-III. c Similar to b in SU-DIPG-V. d H&E demonstrating DIPG tumor at the frontal horn of the lateral ventricle in SU-DIPG-XIII. e H&E stain (left) and Ki67 immunostaining (right image) illustrating tumor infiltration in the lateral ventricle SVZ of SU-DIPG-VI. f H&E (left) and nestin immunostaining (right) of DIPG tumor in the third ventricle of SU-DIPG-IV. Immunostains DAB with hematoxylin counterstain. Scale bars 1.25 mm (b–c, d, left panel), 250 μm (d, right panel; e, f)
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