Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Sep;20(9):821-30.
doi: 10.1111/1469-0691.12719.

The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide

P Nordmann  1 , L Poirel
Affiliations
Free article
Review

The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide

P Nordmann et al. Clin Microbiol Infect. 2014 Sep.
Free article

Abstract

The spread of carbapenemase producers in Enterobacteriaceae has now been identified worldwide. Three main carbapenemases have been reported; they belong to three classes of β-lactamases, which are KPC, NDM, and OXA-48. The main reservoirs of KPC are Klebsiella pneumoniae in the USA, Israel, Greece, and Italy, those of NDM are K. pneumoniae and Escherichia coli in the Indian subcontinent, and those of OXA-48 are K. pneumoniae and Escherichia coli in North Africa and Turkey. KPC producers have been mostly identified among nosocomial isolates, whereas NDM and OXA-48 producers are both nosocomial and community-acquired pathogens. Control of their spread is still possible in hospital settings, and relies on the use of rapid diagnostic techniques and the strict implemention of hygiene measures.

Keywords: Carbapenemase; Enterobacteriaceae; KPC; NDM; OXA-48.

PubMed Disclaimer

MeSH terms