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Review
. 2014 Aug;20(8):710-6.
doi: 10.1111/cns.12288. Epub 2014 Jun 16.

Electrical stimulation of cerebellar fastigial nucleus: mechanism of neuroprotection and prospects for clinical application against cerebral ischemia

Jian Wang  1 , Wei-Wei Dong, Wen-Hua Zhang, Jian Zheng, Xin Wang
Affiliations
Review

Electrical stimulation of cerebellar fastigial nucleus: mechanism of neuroprotection and prospects for clinical application against cerebral ischemia

Jian Wang et al. CNS Neurosci Ther. 2014 Aug.

Abstract

For around two decades, electrical fastigial nucleus stimulation (FNS) has been demonstrated to induce neuroprotection involving multiple mechanisms. In this review, we summarize the protective effects of FNS against cerebral ischemia through the inhibition of electrical activity around the lesion, excitotoxic damage on neurons, and brain inflammatory response, as well as apoptosis. Moreover, FNS has been reported to promote nerve tissue repair, reconstruction, and neurological rehabilitation and improve stroke-related complications including poststroke cognitive dysfunction, depression, and abnormal heart rate variability. We thus further discuss the potential of FNS for clinical applications. Given the absence of any risk of inducing sublethal damage, FNS may offer a new approach to preconditioned neuroprotection against cerebral ischemia.

Keywords: Cerebral ischemia; Fastigial nucleus; Neuroprotection; Stroke.

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Conflict of interest statement

The authors have no conflict of interests.

Figures

Figure 1
Figure 1
A schematic diagram illustrating the mechanisms by which ischemia injury neurons and some targets (blue mark) through which fastigial nucleus stimulation provides protection on the neurons.
See this image and copyright information in PMC

References

    1. Miura M, Reis DJ. Cerebellum: A pressor response elicited from the fastigial nucleus and its efferent pathway in brainstem. Brain Res 1969;13:595–599. - PubMed
    1. Del Bo A, Sved AF, Reis DJ. Fastigial stimulation releases vasopressin in amounts that elevate arterial pressure. Am J Physiol 1983;244:H687–H694. - PubMed
    1. Del Bo A, Sved AF, Reis DJ. Inhibitory influences from arterial baroreceptors on vasopressin release elicited by fastigial stimulation in rats. Circ Res 1984;54:248–253. - PubMed
    1. Golanov EV, Reis DJ. Cerebral cortical neurons with activity linked to central neurogenic spontaneous and evoked elevations in cerebral blood flow. Neurosci Lett 1996;209:101–104. - PubMed
    1. Nakai M, Iadecola C, Reis DJ. Global cerebral vasodilation by stimulation of rat fastigial cerebellar nucleus. Am J Physiol 1982;243:H226–H235. - PubMed

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