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Review
. 2014 Aug;10(8):973-5.
doi: 10.1586/1744666X.2014.929944. Epub 2014 Jun 14.

Etiology of leukocyte adhesion deficiency-associated periodontitis revisited: not a raging infection but a raging inflammatory response

George Hajishengallis  1 , Niki M Moutsopoulos
Affiliations
Review

Etiology of leukocyte adhesion deficiency-associated periodontitis revisited: not a raging infection but a raging inflammatory response

George Hajishengallis et al. Expert Rev Clin Immunol. 2014 Aug.

Abstract

In leukocyte adhesion deficiency type I, neutrophils fail to adhere to blood vessel walls and thus cannot transmigrate to peripheral tissues. Leukocyte adhesion deficiency type I patients invariably experience an aggressive form of generalized periodontitis, which has been historically attributed to defective neutrophil surveillance of the periodontal infection. This time-honored notion has now been challenged by a recent study, which showed that the underlying etiology involves a dysregulated host response that leads to overexpression of the proinflammatory and bone-resorptive cytokine IL-17.

Keywords: IL-17; inflammation; leukocyte adhesion deficiency; neutrophils; periodontitis.

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Conflict of interest statement

Conflict of interest

The authors declare no conflicts of interest.

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