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. 2002;6(1):45-7.
doi: 10.1080/136515002753489416.

Fluvoxamine for the treatment of depression and parkinsonism in progressive supranuclear palsy

Tsuyoshi Miyaoka, Haruo Seno, Takuji Inagaki, Jun Horiguchi

Fluvoxamine for the treatment of depression and parkinsonism in progressive supranuclear palsy

Tsuyoshi Miyaoka et al. Int J Psychiatry Clin Pract. 2002.

Abstract

Progressive supranuclear palsy (PSP) is a parkinsonian-like disorder characterized by postural instability, rigidity, bradykinesia, supranuclear ocular palsy, dysarthria, dysphagia and dementia. There is no satisfactory treatment. A 68-year-old woman with initial progressive supranuclear palsy is described, who was generally apathetic, withdrawn, lacked spontaneity in speech and behavior, and suffered episodes of depression. Treatment with levodopa/carbidopa was ineffective in controlling her parkinsonism and depression, but these symptoms responded to fluvoxamine. This response may be related to fluvoxamine's putative effect on the serotonin system.

Keywords: Depression; Fluvoxamine; Palsy; Parkinsonism; Progressive; Supranuclear.

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