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. 2014 Jun;7(6):1839-1842.
doi: 10.3892/ol.2014.2000. Epub 2014 Mar 28.

Adenoma of the nipple: A clinicopathological report of 13 cases

Maurizio DI Bonito  1 , Monica Cantile  1 , Francesca Collina  1 , Massimiliano D'Aiuto  2 , Giuseppina Liguori  1 , Rossella DE Cecio  1 , Gerardo Botti  1
Affiliations

Adenoma of the nipple: A clinicopathological report of 13 cases

Maurizio DI Bonito et al. Oncol Lett. 2014 Jun.

Abstract

Adenoma of the nipple (AN) represents a rare benign mammary proliferation of lactiferous ducts. It appears as an erosive or ulcerative lesion, which in a number of cases is associated with a serous/hematic secretion. AN may be clinically confused with Paget's disease and histologically with invasive breast carcinoma or breast cancer precursor lesions. Therefore, the histological and immunophenotypic analysis is essential for the differential diagnosis. The present study describes the histopathological characteristics of a first case series of AN.

Keywords: immunophenotype; myoepithelial cells; nipple adenoma.

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Figures

Figure 1
Figure 1
Complete resection of the nipple with erythema, superficial ulceration and crusting.
Figure 2
Figure 2
Hematoxylin and eosin morphology. (a) AN lesion overview (magnification, ×10). (b) Papillomatosis pattern with usual ductal hyperplasia (magnification, ×40). (c) Papillomatosis pattern (magnification, ×20). (d) Mixed pattern (papillomatosis and adenosis; magnification, ×20). Adenosis pattern with (e) myoepithelial hyperplasia (magnification, ×40) and (f) keratocysts (magnification, ×20). AN, adenoma of the nipple..
Figure 3
Figure 3
Immunophenotyping. (a) M-actin, (b) p63, (c) cytokeratin 5/6 and (d) cladesmon 1 staining in AN with papillomatosis pattern and (e) p63 and (f) M-actin staining in AN with adenosis pattern (magnification, ×20). M-actin, α-smooth muscle actin; AN, adenoma of the nipple.
See this image and copyright information in PMC

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