Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2014 Jun 16;9(6):e99044.
doi: 10.1371/journal.pone.0099044. eCollection 2014.

Guidelines for therapeutic drug monitoring of vancomycin: a systematic review

Zhi-Kang Ye  1 , Can Li  1 , Suo-Di Zhai  2
Affiliations
Comparative Study

Guidelines for therapeutic drug monitoring of vancomycin: a systematic review

Zhi-Kang Ye et al. PLoS One. .

Abstract

Background and objective: Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM.

Methods: PubMed, Embase, guidelines' websites and Google were searched for CPGs for vancomycin TDM. Two independent assessors rated the quality of each CPG using the Appraisal of Guidelines for Research & Evaluation II (AGREEII) instrument and data were independently extracted.

Results: Twelve guidelines were evaluated and the overall quality of guidelines for vancomycin TDM was moderate. The highest score was recorded in the domain of clarity of presentation, and the lowest score was recorded in the domain of rigor of development and stakeholder involvement. The specific recommendations for vancomycin TDM were moderately consistent and guidelines varied in trough concentration monitoring, frequency of TDM, and serum concentration targets.

Conclusion: The overall guideline quality for vancomycin TDM was not optimal and effort is needed to improve guideline quality, especially in the domain of rigor of development and stakeholder involvement.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart for the systematic review.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cataldo MA, Tacconelli E, Grilli E, Pea F, Petrosillo N (2012) Continuous versus intermittent infusion of vancomycin for the treatment of Gram-positive infections: systematic review and meta-analysis. J Antimicrob Chemother 67: 17–24. - PubMed
    1. Ye ZK, Tang HL, Zhai SD (2013) Benefits of Therapeutic Drug Monitoring of Vancomycin: A Systematic Review and Meta-Analysis. PLoS ONE 8. - PMC - PubMed
    1. Swartling M, Gupta R, Dudas V, Guglielmo BJ (2012) Short term impact of guidelines on vancomycin dosing and therapeutic drug monitoring. Int J Clin Pharm 34: 282–285. - PubMed
    1. Eiland LS, English TM, Eiland EH (2011) Assessment of Vancomycin Dosing and Subsequent Serum Concentrations in Pediatric Patients. Annals of Pharmacotherapy 45: 582–589. - PubMed
    1. De Cock P, Haegeman E, Goerlandt N, Vanhaesebrouck P, Stove V, et al. (2010) Focused Conference Group: P13 - Maximising benefits and minimizing harms from drugs vancomycin dosing and monitoring in children: Compliance with guidelines in a belgian teaching hospital. Basic and Clinical Pharmacology and Toxicology 107: 250–251.