Listeria exploits damage and death to spread bad news
- PMID: 24934861
- PMCID: PMC4116131
- DOI: 10.1016/j.tim.2014.06.001
Listeria exploits damage and death to spread bad news
Abstract
Pathogenic Listeria monocytogenes replicates within the host cytosol; little is known about how it transits from cell to cell, spreading infection. A recent study implicates infection-induced membrane damage as a trigger for efferocytosis, the recognition and uptake of dead cells, thereby tricking neighboring cells into taking up the invader.
Keywords: Listeria; dissemination; efferocytosis; membrane damage.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment on
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Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread.Nature. 2014 May 8;509(7499):230-4. doi: 10.1038/nature13168. Epub 2014 Apr 13. Nature. 2014. PMID: 24739967 Free PMC article.
References
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- Alberti-Segui C, et al. Differential function of Listeria monocytogenes listeriolysin O and phospholipases C in vacuolar dissolution following cell-to-cell spread. Cell Microbiol. 2007;9:179–195. - PubMed
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