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Comment
. 2014 Jul 18;115(3):335-8.
doi: 10.1161/CIRCRESAHA.114.304616. Epub 2014 Jun 16.

Embryonic stem cell-derived cardiac myocytes are not ready for human trials

Mark E Anderson  1 , Joshua Goldhaber  2 , Steven R Houser  2 , Michel Puceat  2 , Mark A Sussman  2
Affiliations
Comment

Embryonic stem cell-derived cardiac myocytes are not ready for human trials

Mark E Anderson et al. Circ Res. .

Abstract

Recently a preclinical report assessed the efficacy, safety, and feasibility of using human embryonic stem cells to regenerate infarcted myocardium in a non-human primate model. This commentary evaluates that study by pointing out key weaknesses, offering an alternative perspective, and summarizing major unresolved issues. Our conclusion is that significant challenges remain before human embryonic stem cells are ready for use in clinical trials.

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  • Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
    Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ, Gantz JA, Fugate JA, Muskheli V, Gough GM, Vogel KW, Astley CA, Hotchkiss CE, Baldessari A, Pabon L, Reinecke H, Gill EA, Nelson V, Kiem HP, Laflamme MA, Murry CE. Chong JJ, et al. Nature. 2014 Jun 12;510(7504):273-7. doi: 10.1038/nature13233. Epub 2014 Apr 30. Nature. 2014. PMID: 24776797 Free PMC article.

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