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. 2014 Jun 3;11(8):819-23.
doi: 10.7150/ijms.8854. eCollection 2014.

Screening tests using serum tissue transglutaminase IgA may facilitate the identification of undiagnosed celiac disease among Japanese population

Hideyuki Nakazawa  1 , Hideki Makishima  1 , Toshiro Ito  1 , Hiroyoshi Ota  2 , Kayoko Momose  1 , Nodoka Sekiguchi  1 , Kaname Yoshizawa  3 , Taiji Akamatsu  4 , Fumihiro Ishida  5
Affiliations

Screening tests using serum tissue transglutaminase IgA may facilitate the identification of undiagnosed celiac disease among Japanese population

Hideyuki Nakazawa et al. Int J Med Sci. .

Abstract

The prevalence of celiac disease (CD) among Japanese population has been unknown, whereas it has been increasingly recognized in the US and in the European countries. The aim of the present study is to identify possible cases with CD among Japanese population and clarify the relevance of screening for the disease. We conducted a serologic screening for the disease among 710 Japanese patients and 239 healthy volunteers at a local tertiary teaching hospital, using an anti-tissue transglutaminase IgA (TTG-IgA) test, and histological examination of the small intestines from the TTG-IgA positive subjects. There were no TTG-IgA positive sera among the healthy volunteers. Twenty of the patients (2.8%), including eight with malignant lymphoma, were tested positive for TTG-IgA. The histological examination of the eleven patients among those with positive TTG-IgA, seven showed villous atrophy and partial lymphocytes infiltration in the mucosa, which could be compatible to mucosal changes observed in CD. Five of them had non-Hodgkin lymphoma in the gastrointestinal tracts. Serologic tests using TTG-IgA might be relevant to screen for those with undiagnosed CD among Japanese population.

Keywords: anti-tissue transglutaminase IgA; celiac disease; malignant lymphoma; screening.

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Conflict of interest statement

COMPETING INTERESTS: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Scatter diagram of serum anti-tissue transglutaminase IgA antibody (TTG-IgA) in the enrolled subjects.
See this image and copyright information in PMC

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