Why do some patients with type 1 diabetes live so long?

Abstract

While the lifespan of people with type 1 diabetes has increased progressively since the advent of insulin therapy, these patients still experience premature mortality, primarily from cardiovascular disease (CVD). However, a subgroup of those with type 1 diabetes survives well into old age without significant morbidity. It is the purpose of this review to explore the factors which may help in identifying these patients. It might be expected that hyperglycaemia plays a major role in explaining the increased incidence of CVD and mortality of these individuals. However, while a number of publications have associated poor long term glycaemic control with an increase in both all-cause mortality and CVD in those with type 1 diabetes, it is apparent that good glycaemic control alone cannot explain why some patients with type 1 diabetes avoid fatal CVD events. Lipid disorders may occur in those with type 1 diabetes, but the occurrence of elevated high-density lipoprotein-cholesterol is positively associated with longevity in this population. Non-renal hypertension, by itself is a significant risk factor for CVD but if adequately treated does not appear to mitigate against longevity. However, the presence of nephropathy is a major risk factor and its absence after 15-20 years of diabetes appears to be a marker of long-term survival. One of the major factors linked with long-term survival is the absence of features of the metabolic syndrome and more specifically the presence of insulin sensitivity. Genetic factors also play a role, with a family history of longevity and an absence of type 2 diabetes and hypertension in the family being important considerations. There is thus a complex interaction between multiple risk factors in determining which patients with type 1 diabetes are likely to live into older age. However, these patients can often be identified clinically based on a combination of factors as outlined above.

Keywords: Cardiovascular disease; Coronary artery disease; Lipids; Metabolic syndrome; Prognosis; Survival; Type 1 diabetes.

Figure 1

Ischaemic heart disease mortality rates in people with type 1 diabetes vs general population (from: Laing et al[3]).

Figure 2

All-cause mortality and the association of glycaemic control (from: Grauslund et al[7]).

Figure 3

A significant increase in Intima-Media Thickness is seen in patients s with the metabolic syndrome (P = 0.003) (adapted from: Distiller et al[32]).

Figure 4

Complex interactions exist between multiple risk factors in determining the outcome for patients with type 1 diabetes. CVD: Cardiovascular disease.