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. 2013 Sep 29;19(1):47-55.
doi: 10.1016/j.rpor.2013.08.004. eCollection 2014 Jan.

Biological effects and equivalent doses in radiotherapy: A software solution

Cyril Voyant  1 , Daniel Julian  2 , Rudy Roustit  3 , Katia Biffi  4 , Céline Lantieri  4
Affiliations

Biological effects and equivalent doses in radiotherapy: A software solution

Cyril Voyant et al. Rep Pract Oncol Radiother. .

Abstract

Background: The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes.

Aim: We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model).

Materials and methods: THE METHODOLOGY USED DRAWS FROM SEVERAL SOURCES: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames.

Results and conclusions: The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers.

Keywords: Fractionation; Linear quadratic; Radiobiology; Repopulation; Time effect.

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Figures

Fig. 1
Fig. 1
Graphical interface for the LQL_Equiv.
See this image and copyright information in PMC

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