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Comment
. 2014 Jun 17;11(6):e1001665.
doi: 10.1371/journal.pmed.1001665. eCollection 2014 Jun.

Blood transfusions following trauma: finding an evidence-based vein

Druin Burch  1
Affiliations
Comment

Blood transfusions following trauma: finding an evidence-based vein

Druin Burch. PLoS Med. .

Abstract

Druin Burch reflects on new research by Pablo Perel and colleagues and notes that an important fraction of trauma-related deaths could be avoided by improving our knowledge of when to give blood to patients.

Please see later in the article for the Editors' Summary

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Conflict of interest statement

DB has helped with recruitment to the HALT-IT trial of tranexamic acid in upper gastro-intestinal haemorrhages on behalf of the general medical service at the Oxford University Hospitals NHS Trust. The trial is not directly related to the CRASH-2 study but is coordinated by the same research unit. DB received no financial reward for his involvement in the HALT-IT trial.

Comment on

References

    1. World Health Organization (2010) Injuries and violence: the facts. Geneva: World Health Organization.
    1. Perel P, Clayton T, Altman DG, Croft P, Douglas I (2014) Red blood cell transfusion and mortality in trauma patients: risk-stratified analysis of an observational study. PLoS Med 11: e1001664. - PMC - PubMed
    1. CRASH-2 trial collaborators, Shakur H, Roberts I, Bautista R, Caballero J, et al. (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376: : 23–32. Available: http://download.thelancet.com/flatcontentassets/pdfs/S0140673610608355.pdf. Accessed 14 May 2014. - PubMed
    1. World Health Organization Department of Essential Health Technologies (2006) Blood transfusion safety. Geneva: World Health Organization. Available: http://www.who.int/bloodsafety/en/Blood_Transfusion_Safety.pdf. Accessed 14 May 2014.
    1. Shander A, Hofmann A, Ozawa S, Theusinger OM, Gombotz H, et al. (2010) Activity-based costs of blood transfusions in surgical patients at four hospitals. Transfusion 50: 753–765. - PubMed

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